Title
Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel
Christian Rentenberger
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Abstract
Here we show that the well-known ovalbumin epitope SIINFEKL that is routinely used to stimulate ovalbumin-specific T cells and to test new vaccine adjuvants can form a stable hydrogel. We investigate properties of this hydrogel by a range of spectroscopic and imaging techniques demonstrating that the hydrogel is stabilized by self-assembly of the peptide into nanofibres via stacking of β-sheets. As peptide hydrogels are known to stimulate an immune response as adjuvants, the immunoactive properties of the SIINFEKL peptide may also originate from its propensity to self-assemble into a hydrogel. This finding requires a re-evaluation of this epitope in adjuvant testing.
Keywords
Peptide vaccinesPeptides
Object type
Language
English [eng]
Persistent identifier
phaidra.univie.ac.at/o:1177537
Appeared in
Title
Scientific Reports
Volume
9
ISSN
2045-2322
Issued
2019
Publication
Springer Science and Business Media LLC
Version type
Date issued
2019
Access rights
Rights
Rights statement
© The Author(s) 2019
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