Title
Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice
Author
Daniel Segelcke
Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster
Meike Hütte
Somatosensory Signaling and Systems Biology, Max Planck Institute of Experimental Medicine
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Abstract
Chronic pain is a prevalent medical problem, and its molecular basis remains poorly understood. Here, we demonstrate the significance of the transmembrane protein (Tmem) 160 for nerve injury-induced neuropathic pain. An extensive behavioral assessment suggests a pain modality- and entity-specific phenotype in male Tmem160 global knockout (KO) mice: delayed establishment of tactile hypersensitivity and alterations in self-grooming after nerve injury. In contrast, Tmem160 seems to be dispensable for other nerve injury-induced pain modalities, such as non-evoked and movement-evoked pain, and for other pain entities. Mechanistically, we show that global KO males exhibit dampened neuroimmune signaling and diminished TRPA1-mediated activity in cultured dorsal root ganglia. Neither these changes nor altered pain-related behaviors are observed in global KO female and male peripheral sensory neuron-specific KO mice. Our findings reveal Tmem160 as a sexually dimorphic factor contributing to the establishment, but not maintenance, of discrete nerve injury-induced pain behaviors in male mice.
Keywords
chronic painneuropathic painmouse pain behaviorcytokinespain initiationneuro-immune interactionnerve injurydorsal root gangliainflammatory signaling
Object type
Language
English [eng]
Persistent identifier
Appeared in
Title
Cell Reports
Volume
37
Issue
12
ISSN
2211-1247
Issued
2021
Publication
Elsevier BV
Version type
Date issued
2021
Access rights
Rights
Rights statement
(c) 2021 The Author(s)
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