Title
Does 2’-hydroxygenistein inhibit the endometrial proliferation? A preliminary study
Author
Sylvin Benjamin Ateba
Department of Biology of Animal Organisms, Faculty of Science, University of Douala
Dieudonné Njamen
Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I
Abstract
Isoflavones, due to their claimed or demonstrated beneficial biological activities, have attracted great interest and gained popularity among the public. On the risk of endometrial hyperplasia, conflicting findings for such compounds have been reported and genistein has been intensively studied. Studies also indicated that 2’-hydroxylation of isoflavones can lead to beneficial components with superior bioactivity compared to isoflavones lacking this substituent. Till now there is no study evaluating the effect of 2’-hydroxygenistein on endometrial hyperplasia in vivo. In line with this, a 3-day uterotrophic assay was carried out to evaluate the effect of 2’-hydroxygenistein on the uterus as its endometrial hyperplasia is of significant clinical concern. Daily subcutaneous administration of 2’-hydroxygenistein significantly (p ? 0.05) increased uterine wet weight at 2 and 8 mg/kg/day, while it reduced (p ? 0.05) uterine epithelial height at all tested doses. In contrast, no significant variation was observed on vaginal epithelial height. As global result, it appears that 2’-hydroxygenistein might exhibit anti-proliferative effects in the uterus, while having no effect on the vagina. However, this aspect needs to be further investigated.
Keywords
2’-Hydroxygenisteinuterotrophic assayendometrial proliferation
Object type
Language
English [eng]
Persistent identifier
Appeared in
Title
The Journal of Phytopharmacology
Volume
10
Issue
3
ISSN
2320-480X
Issued
2021
From page
196
To page
200
Publication
BioMed Research Publishers
Version type
Date issued
2021
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Rights
Rights statement
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