Title
The Impact of Music on Stress Biomarkers: Protocol of a Substudy of the Cluster-Randomized Controlled Trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL)
Author
Naomi L. Rasing
Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen
Sarah I. M. Janus
Department of General Practice and Elderly Care Medicine, University of Groningen, University Medical Center Groningen
Gunter Kreutz
Department of Music, Speech and Music Lab, Carl von Ossietzky University Oldenburg
... show all
Abstract
Recently, a large cluster-randomized controlled trial was designed—Music Interventions for Dementia and Depression in ELderly care (MIDDEL)—to assess the effectiveness of music interventions on depression in care home residents with dementia (ClinicalTrials.gov NCT03496675). To understand the pathophysiological mechanisms, we observed the effect of repeated music interventions on stress in this population since chronic stress was associated with depression and an increased risk for dementia. An exploratory study was designed to assess: (1) changes in hair cortisol concentrations as an indicator of longer-term stress; (2) whether baseline stress is a predictor of therapy outcome; (3) pre- and post-treatment effects on salivary α-amylase and cortisol response as an indicator of immediate stress in 180–200 care home residents with dementia and depressive symptoms who partake in the MIDDEL trial. Insights into mediatory effects of stress to explain the effect of music interventions will be gained. Hair cortisol concentrations were assessed at baseline and at 3, 6, and 12 months along with the Perceived Stress Scale. Salivary α-amylase and cortisol concentrations were assessed at 1, 3, and 6 months. Saliva was collected just before a session and 15 and 60 min after a session, along with a stress Visual Analogue Scale.
Keywords
alpha-amylasecortisolmusic therapymusic-based therapies and interventionssalivahairbiomarkersdementiadepressionelderly care
Object type
Language
English [eng]
Persistent identifier
phaidra.univie.ac.at/o:1666673
Appeared in
Title
Brain Sciences
Volume
12
Issue
4
ISSN
2076-3425
Issued
2022
Publication
MDPI AG
Version type
Date issued
2022
Access rights
Rights
Rights statement
© 2022 by the authors
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