Titel
Type I Interferons in Bacterial Infections: A Balancing Act
Autor*in
Pavel Kovarik
Max F. Perutz Laboratories, Universität Wien
Autor*in
Virginia Castiglia
Max F. Perutz Laboratories, Universität Wien
Autor*in
Masa Ivin
Max F. Perutz Laboratories, Universität Wien
... show all
Abstract
Defense against bacterial infections requires activation of the immune response as well as timely reestablishment of tissue and immune homeostasis. Instauration of homeostasis is critical for tissue regeneration, wound healing, and host recovery. Recent studies revealed that severe infectious diseases frequently result from failures in homeostatic processes rather than from inefficient pathogen eradication. Type I interferons (IFN) appear to play a key role in such processes. Remarkably, the involvement of type I IFNs in the regulation of immune and tissue homeostasis upon bacterial insult may have beneficial or detrimental consequences for the host. The reasons for such ambivalent function of type I IFNs are not understood. The disparate effects of type I IFNs on bacterial infections are in marked contrast to their well-established protective roles in most viral infections. In this review, we will focus on type I IFN effector mechanisms which balance processes involved in immune and tissue homeostasis during specific bacterial infections and highlight the most important missing links in our understanding of type I IFN functions.
Stichwort
type I interferonbacterial infectioncytokineschemokinesinnate immunityresilience to infectionsimmunomodulationimmunosuppression
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:528069
Erschienen in
Titel
Frontiers in Immunology
Band
7
Verlag
Frontiers Media SA
Erscheinungsdatum
2016
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