Titel
Antioxidant Properties and the Formation of Iron Coordination Complexes of 8-Hydroxyquinoline
Autor*in
Franz Hadacek
Department of Plant Biochemistry, Albrecht-von-Haller Institut, Georg-August-Universität Göttingen
... show all
Abstract
Background: The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegenerative agent. However, other authors noted pro-oxidant effects of 8HQ. Here, we explore the pro- and antioxidant properties of 8HQ, especially in context of coordination complexes with iron (II) and iron (III). Methods: Nano-electrospray−mass spectrometry, differential pulse voltammetry, deoxyribose degradation, iron (II) autoxidation, and brine shrimp mortality assays were used. Results: 8HQ formed a complex mixture of coordination complexes with iron (II) and iron (III). Furthermore, 8HQ showed antioxidant effects but no pro-oxidant ones. In the brine shrimp mortality assay, 8HQ demonstrated toxicity that decreased in the presence of iron (III). Conclusions: 8HQ is a potent antioxidant whose effects depend not only on the formation of the coordination complexes with iron ions, but surely on the scavenging activities due to the redox properties of the 8-hydroxyl group. No pro-oxidant effects were observed in the set of the used assays.
Stichwort
Alzheimer’sFenton reactionhydroxyl radicaliron chelatesreactive oxygen species
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
International Journal of Molecular Sciences
Band
19
Ausgabe
12
Seitenanfang
3917
Publication
MDPI AG
Erscheinungsdatum
2018
Zugänglichkeit
Rechte
Rechteangabe
© 2018 by the authors
Universität Wien | Universitätsring 1 | 1010 Wien | T
+43-1-4277-0