Titel
Yersinia pestis Interacts With SIGNR1 (CD209b) for Promoting Host Dissemination and Infection
Autor*in
Kun Yang
Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Yingxia He
Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Chae Gyu Park
Laboratory of Immunology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Science Institute, Yonsei University College of Medicine
... show all
Abstract
Yersinia pestis, a Gram-negative bacterium and the etiologic agent of plague, has evolved from Yersinia pseudotuberculosis, a cause of a mild enteric disease. However, the molecular and biological mechanisms of how Y. pseudotuberculosis evolved to such a remarkably virulent pathogen, Y. pestis, are not clear. The ability to initiate a rapid bacterial dissemination is a characteristic hallmark of Y. pestis infection. A distinguishing characteristic between the two Yersinia species is that Y. pseudotuberculosis strains possess an O-antigen of lipopolysaccharide (LPS) while Y. pestis has lost the O-antigen during evolution and therefore exposes its core LPS. In this study, we showed that Y. pestis utilizes its core LPS to interact with SIGNR1 (CD209b), a C-type lectin receptor on antigen presenting cells (APCs), leading to bacterial dissemination to lymph nodes, spleen and liver, and the initiation of a systemic infection. We therefore propose that the loss of O-antigen represents a critical step in the evolution of Y. pseudotuberculosis into Y. pestis in terms of hijacking APCs, promoting bacterial dissemination and causing the plague.
Stichwort
Yersinia pestisSIGNR1 (CD209b)macrophagesdendritic cells (DCs)antigen presenting cells
(APCs)core lipopolysaccharide/lipooligosaccharides (core LPS/LOS)bacterial disseminationhost-pathogen
interactions
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Frontiers in Immunology
Band
10
ISSN
1664-3224
Erscheinungsdatum
2019
Publication
Frontiers Media SA
Erscheinungsdatum
2019
Zugänglichkeit
Rechte
Rechteangabe
© 2019 Yang, He, Park, Kang, Zhang, Han, Cui, Bulgheresi, Anisimov,
Dentovskaya, Ying, Jiang, Ding, Njiri, Zhang, Zheng, Xia, Kan, Wang, Jing, Yan, Li,
Wang, Xiamu, Chen, Ma, Bartra, Plano, Klena, Yang, Skurnik and Chen
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