Titel
Structural Insight into the In Vitro Anti-Intravasative Properties of Flavonoids
Autor*in
Julia Eichsteininger
Kerstin Kirisits
Department of Pathology, Medical University of Vienna
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Abstract
We investigated the effect of 21 flavonoids in a three-dimensional in vitro system for their ability to inhibit gap formation by MCF-7 breast cancer spheroids in monolayers of lymphendothelial cells. Different representatives of the classes of flavones, flavonols, and flavanones were tested in the circular chemorepellent-induced defects (CCID)-assay. Bay11-7082, a known inhibitor of CCID formation served as the positive control. This study provides the first comparison of the potential of flavonoids to suppress features influencing the intravasation of MCF-7 breast cancer cells aggregates through the lymph endothelial barrier. The most significant effects were seen after incubation with the flavones luteolin, chrysin, and apigenin. Additional hydroxylation or methoxylation in positions 6 or 8, as expected, resulted in decreased activity. The tested flavanones remained without or low efficacy.
Stichwort
CCID assayinhibition of gap formationflavonoidsanti-invasivebreast cancerstructure-activity relationship
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Scientia Pharmaceutica
Band
87
Ausgabe
3
ISSN
2218-0532
Erscheinungsdatum
2019
Publication
MDPI AG
Erscheinungsdatum
2019
Zugänglichkeit
Rechte
Rechteangabe
© 2019 by the authors
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