Titel
Smart Protein‐Based Formulation of Dendritic Mesoporous Silica Nanoparticles: Toward Oral Delivery of Insulin
Autor*in
Romain Caillard
Aventus Innovations
... show all
Abstract
Oral insulin administration still represents a paramount quest that almost a century of continuous research attempts did not suffice to fulfill. Before pre-clinical development, oral insulin products have first to be optimized in terms of encapsulation efficiency, protection against proteolysis, and intestinal permeation ability. With the use of dendritic mesoporous silica nanoparticles (DMSNs) as an insulin host and together with a protein-based excipient, succinylated β-lactoglobulin (BL), pH-responsive tablets permitted the shielding of insulin from early release/degradation in the stomach and mediated insulin permeation across the intestinal cellular membrane. Following an original in vitro cellular assay based on insulin starvation, direct cellular fluorescent visualization has evidenced how DMSNs could ensure the intestinal cellular transport of insulin.
Stichwort
beta-lactoglobulin tabletscellular insulin starvationdendritic mesoporous silica nanoparticlesoral insulin dosagetranscellular epithelial transport
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Chemistry – A European Journal
Band
26
Ausgabe
23
ISSN
0947-6539
Erscheinungsdatum
2020
Seitenanfang
5195
Seitenende
5199
Publication
Wiley
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
© 2020 The Authors
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