Titel
Highly Sensitive Virome Characterization of Aedes aegypti and Culex pipiens Complex from Central Europe and the Caribbean Reveals Potential for Interspecies Viral Transmission
Autor*in
Jakob Thannesberger
Division of Infectious Diseases, Department of Medicine 1, Medical University of Vienna
Anna Eisenmann
Division of Infectious Diseases, Department of Medicine 1, Medical University of Vienna
... show all
Abstract
Mosquitoes are the most important vectors for arthropod-borne viral diseases. Mixed viral infections of mosquitoes allow genetic recombination or reassortment of diverse viruses, turning mosquitoes into potential virologic mixing bowls. In this study, we field-collected mosquitoes of different species (Aedes aegypti and Culex pipiens complex), from different geographic locations and environments (central Europe and the Caribbean) for highly sensitive next-generation sequencing-based virome characterization. We found a rich virus community associated with a great diversity of host species. Among those, we detected a large diversity of novel virus sequences that we could predominately assign to circular Rep-encoding single-stranded (CRESS) DNA viruses, including the full-length genome of a yet undescribed Gemykrogvirus species. Moreover, we report for the first time the detection of a potentially zoonotic CRESS-DNA virus (Cyclovirus VN) in mosquito vectors. This study expands the knowledge on virus diversity in medically important mosquito vectors, especially for CRESS-DNA viruses that have previously been shown to easily recombine and jump the species barrier.
Stichwort
mosquito viromeCRESS-DNA virusesCyCV-VNinsect-specific virusesISVBatCV
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:1246955
Erschienen in
Titel
Pathogens
Band
9
Ausgabe
9
ISSN
2076-0817
Erscheinungsdatum
2020
Publication
MDPI AG
Erscheinungsdatum
2020
Zugänglichkeit
Rechte
Rechteangabe
© 2020 by the authors
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