Titel
Analysis of Human Faecal Host Proteins: Responsiveness to 10-Week Dietary Intervention Modifying Dietary Protein Intake in Elderly Males
Autor*in
Jessica L. Gathercole
Proteins and Metabolites Team, AgResearch, New Zealand
Anita J. Grosvenor
Proteins and Metabolites Team, AgResearch, New Zealand
Erin Lee
Proteins and Metabolites Team, AgResearch, New Zealand
... show all
Abstract
Faecal proteomics targeting biomarkers of immunity and inflammation have demonstrated clinical application for the identification of changes in gastrointestinal function. However, there are limited comprehensive analyses of the host faecal proteome and how it may be influenced by dietary factors. To examine this, the Homo sapiens post-diet proteome of older males was analysed at the completion of a 10-week dietary intervention, either meeting the minimum dietary protein recommendations (RDA; n = 9) or twice the recommended dietary allowance (2RDA, n = 10). The host faecal proteome differed markedly between individuals, with only a small subset of proteins present in ≥ 60% of subjects (14 and 44 proteins, RDA and 2RDA, respectively, with only 7 common to both groups). No differences were observed between the diet groups on the profiles of host faecal proteins. Faecal proteins were detected from a wide range of protein classes, with high inter-individual variation and absence of obvious impact in response to diets with markedly different protein intake. This suggests that well-matched whole food diets with two-fold variation in protein intake maintained for 10 weeks have minimal impact on human faecal host proteins.
Stichwort
faecesdietary proteinhost proteinsgastrointestinal healthproteomics
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Frontiers in Nutrition
Band
7
ISSN
2296-861X
Erscheinungsdatum
2021
Publication
Frontiers Media SA
Erscheinungsdatum
2021
Zugänglichkeit
Rechte
Rechteangabe
Copyright © 2021 Gathercole, Grosvenor, Lee, Thomas, Mitchell, Zeng, D’Souza, Ramzan, Sharma, Knowles, Roy, Sjödin, Wagner, Milan, Mitchell and Cameron-Smith.
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