Titel
Tyraminergic corollary discharge filters reafferent perception in a chemosensory neuron
Autor*in
Abstract
Interpreting sensory information requires its integration with the current behavior of the animal. However, how motor-related circuits influence sensory information processing is incompletely understood. Here, we report that current locomotor state directly modulates the activity of BAG CO2 sensory neurons in Caenorhabditis elegans. By recording neuronal activity in animals freely navigating CO2 landscapes, we found that during reverse crawling states, BAG activity is suppressed by tyraminergic corollary discharge signaling. We provide genetic evidence that tyramine released from the RIM reversal interneurons extrasynaptically activates the inhibitory chloride channel LGC-55 in BAG. Disrupting this pathway genetically leads to excessive behavioral responses to CO2 stimuli. Moreover, we find that LGC-55 signaling cancels out perception of self-produced CO2 and O2 stimuli when animals reverse into their own gas plume in ethologically relevant aqueous environments. Our results show that sensorimotor integration involves corollary discharge signals directly modulating chemosensory neurons.
Stichwort
Caenorhabditis eleganscorollary dischargeefference copyreafference perceptioncarbon dioxide sensationtyraminergic neurotransmissionligand-gated chloride channelextrasynaptic signaling
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
phaidra.univie.ac.at/o:1634805
Erschienen in
Titel
Current Biology
Band
32
Ausgabe
14
ISSN
0960-9822
Erscheinungsdatum
2022
Seitenanfang
3048
Seitenende
3058
Publication
Elsevier BV
Erscheinungsdatum
2022
Zugänglichkeit
Rechte
Rechteangabe
(c) 2022 The Author(s)
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