Titel
Fructose: a modulator of intestinal barrier function and hepatic health?
Autor*in
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Abstract
Purpose: Consumption of fructose has repeatedly been discussed to be a key factor in the development of health disturbances such as hypertension, diabetes type 2, and non-alcoholic fatty liver disease. Despite intense research efforts, the question if and how high dietary fructose intake interferes with human health has not yet been fully answered.
Results: Studies suggest that besides its insulin-independent metabolism dietary fructose may also impact intestinal homeostasis and barrier function. Indeed, it has been suggested by the results of human and animal as well as in vitro studies that fructose enriched diets may alter intestinal microbiota composition. Furthermore, studies have also shown that both acute and chronic intake of fructose may lead to an increased formation of nitric oxide and a loss of tight junction proteins in small intestinal tissue. These alterations have been related to an increased translocation of pathogen-associated molecular patterns (PAMPs) like bacterial endotoxin and an induction of dependent signaling cascades in the liver but also other tissues.
Conclusion: In the present narrative review, results of studies assessing the effects of fructose on intestinal barrier function and their impact on the development of health disturbances with a particular focus on the liver are summarized and discussed.
Stichwort
SugarIntestinal barrierTight junctionsNitric oxideIntestinal microbiota
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
European Journal of Nutrition
Band
62
Ausgabe
8
ISSN
1436-6207
Erscheinungsdatum
2023
Seitenanfang
3113
Seitenende
3124
Publication
Springer Science and Business Media LLC
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
Rechteangabe
© The Author(s) 2023
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