Titel
DrForna: visualization of cotranscriptional folding
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Abstract
Motivation: Understanding RNA folding at the level of secondary structures can give important insights concerning the function of a molecule. We are interested to learn how secondary structures change dynamically during transcription, as well as whether particular secondary structures form already during or only after transcription. While different approaches exist to simulate cotranscriptional folding, the current strategies for visualization are lagging behind. New, more suitable approaches are necessary to help with exploring the generated data from cotranscriptional folding simulations. Results: We present DrForna, an interactive visualization app for viewing the time course of a cotranscriptional RNA folding simulation. Specifically, users can scroll along the time axis and see the population of structures that are present at any particular time point. Availability and implementation: DrForna is a JavaScript project available on Github at https://github.com/ViennaRNA/drforna and deployed at https://viennarna.github.io/drforna
Stichwort
Computational MathematicsComputational Theory and MathematicsComputer Science ApplicationsMolecular BiologyBiochemistryStatistics and Probability
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:2041574
Erschienen in
Titel
Bioinformatics
Band
39
Ausgabe
9
ISSN
1367-4811
Erscheinungsdatum
2023
Verlag
Oxford University Press (OUP)
Erscheinungsdatum
2023
Zugänglichkeit
Rechteangabe
© The Author(s) 2023

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