eggNOG 6.0: enabling comparative genomics across 12 535 organisms

Ana Hernández-Plaza; Damian Szklarczyk; Jorge Botas; Carlos P Cantalapiedra; Joaquín Giner-Lamia; Daniel R Mende; Rebecca Kirsch; Thomas Rattei; Ivica Letunic; Lars J Jensen; Peer Bork; Christian von Mering; Jaime Huerta-Cepas

doi:10.1093/nar/gkac1022

Titel

eggNOG 6.0: enabling comparative genomics across 12 535 organisms

Autor*in

Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC)

Damian Szklarczyk

Department of Molecular Life Sciences, University of Zurich

Jorge Botas

Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC)

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Abstract

The eggNOG (evolutionary gene genealogy Non-supervised Orthologous Groups) database is a bioinformatics resource providing orthology data and comprehensive functional information for organisms from all domains of life. Here, we present a major update of the database and website (version 6.0), which increases the number of covered organisms to 12 535 reference species, expands functional annotations, and implements new functionality. In total, eggNOG 6.0 provides a hierarchy of over 17M orthologous groups (OGs) computed at 1601 taxonomic levels, spanning 10 756 bacterial, 457 archaeal and 1322 eukaryotic organisms. OGs have been thoroughly annotated using recent knowledge from functional databases, including KEGG, Gene Ontology, UniProtKB, BiGG, CAZy, CARD, PFAM and SMART. eggNOG also offers phylogenetic trees for all OGs, maximising utility and versatility for end users while allowing researchers to investigate the evolutionary history of speciation and duplication events as well as the phylogenetic distribution of functional terms within each OG. Furthermore, the eggNOG 6.0 website contains new functionality to mine orthology and functional data with ease, including the possibility of generating phylogenetic profiles for multiple OGs across species or identifying single-copy OGs at custom taxonomic levels. eggNOG 6.0 is available at eggnog6.embl.de.

Stichwort

Genetics

Objekt-Typ

journal article

Sprache

Englisch [eng]

Persistent identifier

https://phaidra.univie.ac.at/o:2051100

DOI

10.1093/nar/gkac1022

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