Titel
AutoCore: A network-based definition of the core module of human autoimmunity and autoinflammation
Autor*in
Salvo Danilo Lombardo
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
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Abstract
Although research on rare autoimmune and autoinflammatory diseases has enabled definition of nonredundant regulators of homeostasis in human immunity, because of the single gene-single disease nature of many of these diseases, contributing factors were mostly unveiled in sequential and noncoordinated individual studies. We used a network-based approach for integrating a set of 186 inborn errors of immunity with predominant autoimmunity/autoinflammation into a comprehensive map of human immune dysregulation, which we termed “AutoCore.” The AutoCore is located centrally within the interactome of all protein-protein interactions, connecting and pinpointing multidisease markers for a range of common, polygenic autoimmune/autoinflammatory diseases. The AutoCore can be subdivided into 19 endotypes that correspond to molecularly and phenotypically cohesive disease subgroups, providing a molecular mechanism–based disease classification and rationale toward systematic targeting for therapeutic purposes. Our study provides a proof of concept for using network-based methods to systematically investigate the molecular relationships between individual rare diseases and address a range of conceptual, diagnostic, and therapeutic challenges.
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
Science Advances
Band
9
Ausgabe
35
ISSN
2375-2548
Erscheinungsdatum
2023
Publication
American Association for the Advancement of Science (AAAS)
Erscheinungsdatum
2023
Zugänglichkeit
Rechte
Rechteangabe
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