Title
Impact of Chlorella vulgaris Bioremediation and Selenium on Genotoxicity, Nephrotoxicity and Oxidative/Antioxidant Imbalance Induced by Polystyrene Nanoplastics in African Catfish (Clarias gariepinus)
Author
Shimaa A. Abdelbaky
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University
Author
Zakaria M. Zaky
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University
Author
Doha Yahia
Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University
... show all
Abstract
Contamination of the environment with nano- and microplastic particles exerts a threatening impact on the aquatic ecosystems and sustainable catfish aquaculture. The presence of nanoplastics has been found to have a detrimental impact on both aquatic and terrestrial ecosystems. The present study examines the effect of polystyrene nanoplastics (PS NPs) on the DNA, erythrocytes, oxidative status and renal histology of catfish, in addition to the potential protective effects of Chlorella vulgaris bioremediation and selenium to hinder this effect. Six equal groups of fish were used as follows: Group 1 served as a control group and received water free from PS NPs; Group 2 was exposed to PS NPs at a concentration of 5 mg/L; Group 3 was exposed to PS NPs (5 mg/L) + selenium (1 mg/kg diet); Group 4 was exposed to PS NPs (5 mg/L) + C. vulgaris (25 g/kg diet); Group 5 was supplemented with C. vulgaris (25 g/kg diet); and Group 6 was supplemented with selenium (1 mg/kg diet). The exposure period was 30 days. The results indicated that PS NPs induced oxidative stress by significantly elevating malondialdehyde activities and slightly reducing antioxidant biomarkers, resulting in DNA damage, increased frequency of micronuclei, erythrocyte alterations, and numerous histopathological alterations in kidney tissue. Selenium and C. vulgaris significantly ameliorated the oxidative/antioxidant status, reducing DNA damage, micronucleus frequency, erythrocyte alterations, and improving the morphology of kidney tissue. Nevertheless, further research is needed for a profound understanding of the mechanism behind the toxicity of nano-microplatics in aquatic systems.
Keywords
polystyrene nanoplasticsoxidative stressnephrotoxicitygenotoxicitybioremediationseleniumChlorella vulgaris
Object type
Language
English [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:2082515
Appeared in
Title
Fishes
Volume
9
Issue
2
ISSN
2410-3888
Issued
2024
Publisher
MDPI AG
Date issued
2024
Access rights
Rights statement
© 2024 by the authors

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