Title
Biomarkers of Aging: From Function to Molecular Biology
Author
David Cameron-Smith
Liggins Institute, University of Auckland
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Abstract
Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of biomarkers is further complicated by the diversity of biological living situations, lifestyle activities and medical treatments. Thus, there has been no identification of a single biomarker or gold standard tool that can monitor successful or healthy aging. Within this short review the current knowledge of putative biomarkers is presented, focusing on their application to the major physiological mechanisms affected by the aging process including physical capability, nutritional status, body composition, endocrine and immune function. This review emphasizes molecular and DNA-based biomarkers, as well as recent advances in other biomarkers such as microRNAs, bilirubin or advanced glycation end products.
Keywords
agingbiomarkerphysical functioninflammagingDNA based markermolecular markermiRNA
Object type
Language
English [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:514790
Appeared in
Title
Nutrients
Volume
8
Issue
6
From page
338
Publisher
MDPI AG
Date issued
2016
Access rights
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