Titel
A Coarse-Grained Approach to Protein Design: Learning from Design to Understand Folding
Autor*in
Abstract
Computational studies have given a great contribution in building our current understanding of the complex behavior of protein molecules; nevertheless, a complete characterization of their free energy landscape still represents a major challenge. Here, we introduce a new coarse-grained approach that allows for an extensive sampling of the conformational space of a large number of sequences. We explicitly discuss its application in protein design, and by studying four representative proteins, we show that the method generates sequences with a relatively smooth free energy surface directed towards the target structures.
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
Erschienen in
Titel
PLoS ONE
Band
6
Ausgabe
7
Seitenanfang
e20853-1
Seitenende
e20853-8
Erscheinungsdatum
01.07.2011
Zugänglichkeit
Rechte
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