Titel
Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints
Autor*in
Patrick Fried
Department for Biosystems Science and Engineering, ETH Zurich
... show all
Abstract
BMP signaling plays a crucial role in the establishment of the dorso-ventral body axis in bilaterally symmetric animals. However, the topologies of the bone morphogenetic protein (BMP) signaling networks vary drastically in different animal groups, raising questions about the evolutionary constraints and evolvability of BMP signaling systems. Using loss-of-function analysis and mathematical modeling, we show that two signaling centers expressing different BMPs and BMP antagonists maintain the secondary axis of the sea anemone Nematostella. We demonstrate that BMP signaling is required for asymmetric Hox gene expression and mesentery formation. Computational analysis reveals that network parameters related to BMP4 and Chordin are constrained both in Nematostella and Xenopus, while those describing the BMP signaling modulators can vary significantly. Notably, only chordin, but not bmp4 expression needs to be spatially restricted for robust signaling gradient formation. Our data provide an explanation of the evolvability of BMP signaling systems in axis formation throughout Eumetazoa.
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:447463
Erschienen in
Titel
Cell Reports
Band
10
Ausgabe
10
Seitenanfang
1646
Seitenende
1654
Verlag
Elsevier BV
Erscheinungsdatum
2015
Zugänglichkeit

Herunterladen

Universität Wien | Universitätsring 1 | 1010 Wien | T +43-1-4277-0