• Cynaropicrin: A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent

    • Mahmoud F. Elsebai
      Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University
    • Andrei Mocan
      Department of Pharmaceutical Botany, Iuliu Haţieganu University of Medicine and Pharmacy
    • Atanas G. Atanasov
      Department für Pharmakognosie, Fakultät für Lebenswissenschaften, Universität Wien
  • The different pharmacologic properties of plants-containing cynaropicrin, especially artichokes, have been known for many centuries. More recently, cynaropicrin exhibited a potential activity against all genotypes of hepatitis C virus (HCV). Cynaropicrin has also shown a wide range of other pharmacologic properties such as anti-hyperlipidemic, anti-trypanosomal, anti-malarial, antifeedant, antispasmodic, anti-photoaging, and anti-tumor action, as well as activation of bitter sensory receptors, and anti-inflammatory properties (e.g., associated with the suppression of the key pro-inflammatory NF-κB pathway). These pharmacological effects are very supportive factors to its outstanding activity against HCV. Structurally, cynaropicrin might be considered as a potential drug candidate, since it has no violations for the rule of five and its water-solubility could allow formulation as therapeutic injections. Moreover, cynaropicrin is a small molecule that can be easily synthesized and as the major constituent of the edible plant artichoke, which has a history of safe dietary use. In summary, cynaropicrin is a promising bioactive natural product that, with minor hit-to-lead optimization, might be developed as a drug for HCV.

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  • http://phaidra.univie.ac.at/o:528085

  • Wissenschaftlicher Artikel

  • Veröffentlichte Version

  • 2016

  • 7

  • Frontiers Media SA

  • Englisch

  • Frei zugänglich

  • P25971-B23 – Fonds zur Förderung der wissenschaftlichen Forschung (FWF)

  • 1663-9812

  • cynaropicrin; anti-hepatitis C virus; anti-hyperlipidemic; antitumor; anti-inflammatory; anti-parasite; antibacterial; anti-gastritis action