Titel
Oxaliplatin reacts with DMSO only in the presence of water
Autor*in
Daniel Ortiz
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL)
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Abstract
Herein we show that oxaliplatin reacts rapidly with DMSO in aqueous solutions, despite being stable in pure DMSO and pure water. Furthermore, the reactivity of the clinically applied Pt(II) drugs in water/DMSO and PBS/DMSO mixtures, and the nature of the species formed were investigated by MS, NMR and RP-HPLC techniques.
Objekt-Typ
Sprache
Englisch [eng]
Persistent identifier
https://phaidra.univie.ac.at/o:561669
Erschienen in
Titel
Dalton Transactions
Band
46
Ausgabe
28
Seitenanfang
8929
Seitenende
8932
Verlag
Royal Society of Chemistry (RSC)
Erscheinungsdatum
2017
Zugänglichkeit
Lizenz
Universität Wien | Universitätsring 1 | 1010 Wien | T
+43-1-4277-0