Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin
Autor*in
Yulia N. Nosova
Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University
Autor*in
Ilia V. Zenin
Department of Medicinal Chemistry and Fine Organic Synthesis, Lomonosov Moscow State University
Autor*in
Varvara P. Maximova
Blokhin Cancer Research Center
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Abstract
We present the synthesis and cytotoxic potencies of new Pt(IV) complexes with bexarotene, an anticancer drug that induces cell differentiation and apoptosis via selective activation of retinoid X receptors. In these complexes bexarotene is positioned as an axial ligand. The complex of one bexarotene ligand attached to Pt(IV) oxaliplatin moiety was potent whereas its counterpart carrying two bexarotene ligands was inactive.