We study the low-regularity (in-)extendibility of spacetimes within the synthetic-geometric framework of Lorentzian length spaces developed in Kunzinger and Sämann (Ann Glob Anal Geom 54(3):399–447, 2018). To this end, we introduce appropriate notions of geodesics and timelike geodesic completeness and prove a general inextendibility result. Our results shed new light on recent analytic work in this direction and, for the first time, relate low-regularity inextendibility to (synthetic) curvature blow-up.